Skip NavigationSkip to Content
Return Return to Search Results

Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy

  1. Author:
    Shebzukhov, Y. V.
    Koroleva, E. P.
    Khlgatian, S. V.
    Lagarkova, M. A.
    Meshcheryakov, A. A.
    Lichinitser, M. R.
    Karbach, J.
    Jager, E.
    Kuprash, D. V.
    Nedospasov, S. A.

  2. Author Address

    Moscow MV Lomonosov State Univ, Belozersky Inst PhysicoChem Biol, Dept Mol Immunol, Moscow 119899, Russia. SAIC Frederick Inc, Basic Res Program, NCI Frederick, Frederick, MD 21702 USA. Russian Acad Sci, Lab Mol Immunol, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia. Russian Acad Med Sci, NN Blokhin Canc Res Ctr, Moscow 115478, Russia. Krankenhaus Nordw, Med Klin 2, D-60488 Frankfurt, Germany Nedospasov, SA, Moscow MV Lomonosov State Univ, Belozersky Inst PhysicoChem Biol, Dept Mol Immunol, Vorobjovy Gory, Moscow 119899, Russia
    1. Year: 2005
    2. Date: AUG 15
  2. Journal: Immunology Letters
    1. 100
    2. 1
    3. Pages: 88-93
  4. Type of Article: Article
  1. Abstract:

    Thymidylate synthase (TYMS), the critical enzyme for DNA synthesis and a target for chemotherapy, was recently characterized as an oncogene and a potential target for specific immunotherapy. Here we report TYMS-specific antibody response in a fraction of colon cancer patients. Humoral immune response to TYMS is induced by chemotherapy using TYMS inhibitors, such as 5-fluorouracil (5-FU), and may be associated with tumor burden. Therefore, TYMS may serve as a useful serological biomarker for monitoring the course of disease and treatment in cancer patients. (c) 2005 Elsevier B.V. All rights reserved

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.imlet.2005.06.011
  3. View record in Web of Science®
  4. WOS: 000232422600014

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel