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Mouse Ubc9 knockout: Many path(way)s to ruin

  1. Author:
    Kuehn, M. R.

  2. Author Address

    NCI, Lab Prot Dynam & Signaling, Frederick, MD 21702 USA Kuehn, MR, NCI, Lab Prot Dynam & Signaling, Frederick, MD 21702 USA
    1. Year: 2005
    2. Date: DEC
  2. Journal: Developmental Cell
    1. 9
    2. 6
    3. Pages: 727-728
  4. Type of Article: Article
  1. Abstract:

    In this issue of Developmental Cell, Nacerddine et al. (2005) describe a targeted germ line mutation of the mouse SUMO-specific E2 Ubc9, which abrogates the SUMO conjugation pathway, broadly crippling nuclear function in proliferating cells of the early embryo. This study reveals the wide-ranging roles for this protein modifier in nuclear organization, chromosome segregation, and Ran-driven nucleo-cytoplasmic transport

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External Sources

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  2. DOI: 10.1016/j.devcel.2005.11.008
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