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Importance of communication between producers and consumers of publicly available experimental data

  1. Author:
    Liotta, L. A.
    Lowenthal, M.
    Mehta, A.
    Conrads, T. P.
    Veenstra, T. D.
    Fishman, D. A.
    Petricoin, E. F.

  2. Author Address

    NCI, US FDA, Clin Proteom Program, Off Cell Therapy & Gene Therapy,CBER, Bethesda, MD 20892 USA. NCI, US FDA, Clin Proteom Program, Lab Pathol,CCR, Bethesda, MD 20892 USA. NCI, Inst Biomed Proteom Program, Lab Proteom & Analyt Technol, SAIC Frederick Inc, Frederick, MD 21701 USA. NYU, Natl Ovarian Canc Early Detect Program, New York, NY USA Petricoin, EF, NCI, US FDA, Clin Proteom Program, Off Cell Therapy & Gene Therapy,CBER, Bethesda, MD 20892 USA
    1. Year: 2005
    2. Date: FEB 16
  2. Journal: Journal of the National Cancer Institute
    1. 97
    2. 4
    3. Pages: 310-314
  4. Type of Article: Article
  1. Abstract:

    The application of mass spectrometry to discover new cancer biomarkers is in its infancy. Many of these new markers are low-abundance proteins that exist as fragments associated with carrier proteins. Although reproducibility is key to the use of mass spectrometry for ion fingerprint analysis, the scientific community has yet to establish a common platform or standardized operating procedures that are necessary for intra- and inter-laboratory comparison. In an effort to assist others who are perfecting mass spectrometry platforms for profiling, ongoing experimental data were posted for public consumption. An unintended consequence of unrestricted access to experimental data is the risk of inappropriate conclusions drawn and publicly disseminated that could have been avoided by communication between the producers and consumers of the data. Such disputes, however, should not divert us from the validation of this promising new approach

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External Sources

  1. View record in Web of Science®
  2. WOS: 000227107900015

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