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Differential effects of chemotherapeutic agents on Bcl-2/Bax apoptosis pathway in breast cancer cell

  1. Author:
    Wang, T. T.
    1. Year of Conference: 1997
  2. Conference Name: Annual Meeting of the American Association for Cancer Research
    1. 38
    2. Pages: A769
  4. Type of Work: Meeting Abstract
  1. Abstract:

    The effects of chemotherapeutic agents on Bcl-2/Bax apoptosis pathway were examined in the present study. We found that in estrogen receptor positive human breast cancer cell line MCF-7, treatment with Adriamycin resulted in concentration and time-dependent decreases in Bcl-2 mRNA levels. In addition, Adriamycin treatment also resulted in concentration and time-dependent increases in Bax mRNA levels. Adriamycin also effectively blocked the estradiol-stimulated increase in Bcl-2 mRNA levels, but it's effect on Bax mRNA levels was not affected by estradiol. We also examined possible mechanisms by which treatment of Adriamycin led to changes in Bcl-2 and Bax mRNA levels. The effect of Adriamycin was not affected by preincubation of cell with 1 mM N-acetylcysteine, suggesting that changes in Bcl-2 or Bax mRNA level do not involve the oxidative effects of Adriamycin. We also compared the effects of Adriamycin to that of etoposide, a DNA damaging chemotherapeutic agent. Treatment with Etoposide resulted in increased Bax mRNA but produced no change in Bcl-2 mRNA. These results suggest multiple signaling pathways regulate the Bcl-2/Bax apoptosis pathway and the protective effects of estradiol on cytotoxicity from specific chemotherapeutic agent may depend on the effects of these agents on the Bcl- 2/Bax apoptosis pathway.

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