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Tumour stem cells and drug resistance

  1. Author:
    Dean, M.
    Fojo, T.
    Bates, S.

  2. Author Address

    NCI, Lab Genom Divers, Frederick, MD 21702 USA. NCI, Canc Therapeut Branch, Bethesda, MD 20892 USA Dean, M, NCI, Lab Genom Divers, Frederick, MD 21702 USA
    1. Year: 2005
  2. Journal: Nature Reviews Cancer
    1. 5
    2. 4
    3. Pages: 275-284
  4. Type of Article: Review
  1. Abstract:

    The contribution of tumorigenic stem cells to haematopoietic cancers has been established for some time, and cells possessing stem-cell properties have been described in several solid tumours. Although chemotherapy kills most cells in a tumour, it is believed to leave tumour stem cells behind, which might be an important mechanism of resistance. For example, the ATP-binding cassette (ABC) drug transporters have been shown to protect cancer stem cells from chemotherapeutic agents. Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anticancer strategies

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External Sources

  1. View record in Web of Science®
  2. WOS: 000228091000013

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