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High-resolution crystallography and drug design

  1. Author:
    Cachau, R. E.
    Podjarny, A. D.

  2. Author Address

    IGBMC, F-67404 Illkirch Graffenstaden, France. SAIC Frederick, NCI, ABCC, Frederick, MD 21702 USA Podjarny, AD, IGBMC, 1 Rue Laurent Fries, F-67404 Illkirch Graffenstaden, France
    1. Year: 2005
    2. Date: MAY-JUN
  2. Journal: Journal of Molecular Recognition
    1. 18
    2. 3
    3. Pages: 196-202
  4. Type of Article: Review
  1. Abstract:

    Ultra-high-resolution X-ray crystallography of macromolecules (i.e. resolution better than 0.8 &ANGS;) is a rising field that promises to provide new insight into the structure-function relationships of biomacromolecules. The picture emerging from macromolecular structures at this resolution is far more complex than previously understood, requiring for its study improved tools for structure refinement. analysis and annotation. Some of these problems were highlighted during the recent High Resolution Drug Design Meeting (Bischenberg-Strasbourg, France, 13-16 May 2004). We will review here some or the results and discussions that took place during that meeting and elaborate on the trends and challenges ahead in this emerging new field of research. Copyright © 2005 John Wiley & Sons, Ltd

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External Sources

  1. View record in Web of Science®
  2. WOS: 000229086200003

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