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Transcriptional regulation of NK cell receptors

  1. Author:
    Anderson, S. K.

  2. Author Address

    SAIC Frederick, Basic Res Program, Natl Canc Inst, Frederick, MD 21702 USA.;Anderson, SK, SAIC Frederick, Basic Res Program, Natl Canc Inst, Bldg 560,Rm 31-93, Frederick, MD 21702 USA.;andersn@ncifcrf.gov
    1. Year: 2006
  2. Book Title: Immunobiology of Natural Killer Cell Receptors
  3. Series Title: Current Topics in Microbiology and Immunology
  4. Springer-Verlag Berlin
  5. Berlin
    1. 298
    2. Pages: 59-75
  7. Type of Work: Review
  8. ISBN: 0070-217X
  1. Abstract:

    The stochastic expression of individual members of NK cell receptor gene families on subsets of NK cells has attracted considerable interest in the transcriptional regulation of these genes. Each receptor gene can contain up to three separate promoters with distinct properties. The recent discovery that an upstream Promoter can function as a probabilistic switch element in the Ly49 gene family has revealed a novel mechanism of variegated gene expression. An important question to be answered is whether or not the other NK cell receptor gene families contain probabilistic switches. The promoter elements currently identified in the Ly49, NKR-P1, CD94, NKG2A, and KIR gene families are described.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000235180500003

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