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The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication

  1. Author:
    Yant, L. J.
    Friedrich, T. C.
    Johnson, R. C.
    May, G. E.
    Maness, N. J.
    Enz, A. M.
    Lifson, J. D.
    O'Connor, D. H.
    Carrington, M.
    Watkins, D. I.

  2. Author Address

    Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA. Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53715 USA. NCI, Basic Res Program, Lab Gen Divers, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21702 USA. Sci Appl Int Corp Fredrick, AIDS Vaccine Program, Basic Res Program, Frederick, MD 21072 USA Watkins, DI, Univ Wisconsin, 555 Sci Dr, Madison, WI 53711 USA
    1. Year: 2006
    2. Date: MAY
  2. Journal: Journal of Virology
    1. 80
    2. 10
    3. Pages: 5074-5077
  4. Type of Article: Article
  1. Abstract:

    Particular HLA alleles are associated with reduced human immunodeficiency virus replication. It has been difficult, however, to characterize the immune correlates of viral control. An analysis of the influence of major histocompatibility complex class I alleles on viral control in 181 simian immunodeficiency virus SIVmac239-infected rhesus macaques revealed that Mamu-B*17 was associated with a 26-fold reduction in plasma virus concentrations (P < 0.001). Mamu-B*17 was also enriched 1,000-fold in a group of animals that controlled viral replication. Even after accounting for this group, Mamu-B*17 was associated with an eightfold reduction in plasma virus concentrations (P < 0.001). Mamu-B*17-positive macaques could, therefore, facilitate our understanding of the correlates of viral control

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External Sources

  1. View record in Web of Science®
  2. WOS: 000237457500043

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