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Intranasal Protollin (TM)/F1-V vaccine elicits respiratory and serum antibody responses and protects mice against lethal aerosolized plague infection

  1. Author:
    Jones, T.
    Adamovicz, J. J.
    Cyr, S. L.
    Bolt, C. R.
    Bellerose, N.
    Pitt, L. M.
    Lowell, G. H.
    Burt, D. S.

  2. Author Address

    ID Biomed Corp Quebec, Montreal, PQ H7V 3S8, Canada. USA, Med Res Inst Infect Dis, Ft Detrick, Frederick, MD 21702 USA.;Jones, T, ID Biomed Corp Quebec, 525 Cartier Blvd W, Montreal, PQ H7V 3S8, Canada.;tjones@idbiomedical.com
    1. Year: 2006
    2. Date: Mar
  2. Journal: Vaccine
    1. 24
    2. 10
    3. Pages: 1625-1632
  4. Type of Article: Article
  5. ISSN: 0264-410X
  1. Abstract:

    FIN is a recombinant plague antigen comprising the capsular (F1) and virulence-associated (V) proteins. Given intramuscularly with Alhydrogel, it protects mice against challenge, but is less effective in non-human primates against high-dose aerosolized Yersinia pestis challenge, perhaps because it fails to induce respiratory immunity. Intranasal immunization of mice with F1-V formulated with a Proteosome-based adjuvant (Protollin (TM)), elicited high titers of specific IgA in lungs whereas intranasal F1-V alone or intramuscular Alhydrogel-adsorbed F1-V did not. The Protollin-adjuvanted F1-V vaccine also induced high serum titers of specific IgG, comparable to those induced by intramuscular Alhydrogel-adsorbed F1-V. Mice immunized intranasally with Protollin-F1-V were 100% protected against aerosol challenge with 170 LD50 of Y. pestis and 80% against 255 LD50. (c) 2005 Elsevier Ltd. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.vaccine.2005.09.052
  3. View record in Web of Science®
  4. WOS: 000236259500018

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