Skip NavigationSkip to Content
Return Return to Search Results

Benzoylphenylurea sulfur analogues with potent antitumor activity

  1. Author:
    Hallur, G.
    Jimeno, A.
    Dalrymple, S.
    Zhu, T.
    Jung, M. K.
    Hidaleo, M.
    Isaacs, J. T.
    Sukumar, S.
    Hamel, E.
    Khan, S. R.

  2. Author Address

    Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Div Chem Therapeut, Baltimore, MD 21231 USA. NCI, Toxicol & Pharmacol Branch, Dev Therapeut Program, Div Canc Treatment & Diagnosis,NIH, Frederick, MD 21702 USA. SAIC Frederick Inc, NCI, Frederick, MD 21702 USA.;Khan, SR, Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Div Chem Therapeut, Baltimore, MD 21231 USA.;khansa@jhmi.edu
    1. Year: 2006
    2. Date: Apr
  2. Journal: Journal of Medicinal Chemistry
    1. 49
    2. 7
    3. Pages: 2357-2360
  4. Type of Article: Article
  5. ISSN: 0022-2623
  1. Abstract:

    A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to10-fold increased potency, when compared to I (NSC-639829), against cancer cell lines. 6n was more effective than I in causing apoptosis of MCF-7 cells. When compared to other drugs with a similar mechanism of action, 6n retained significant ability to inhibit tubulin assembly, with an IC50 of 2.1 mu M.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1021/jm051261s
  3. View record in Web of Science®
  4. WOS: 000236593300025

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel