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Decreased CD127 expression on T cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy

  1. Author:
    Read, S. W.
    Higgins, J.
    Metcalf, J. A.
    Stevens, R. A.
    Rupert, A.
    Nason, M. C.
    Lane, H. C.
    Sereti, I.

  2. Author Address

    NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. Sci Applicat Int Corp, AIDS Monitoring Lab, Clin Serv Program, Frederick, MD USA.;Read, SW, NIAID, Immunoregulat Lab, NIH, Rm 11B05,Bldg 10,10 Ctr Dr,MSC 1876, Bethesda, MD 20892 USA.;readsa@niaid.nih.gov
    1. Year: 2006
    2. Date: Aug
  2. Journal: Jaids-Journal of Acquired Immune Deficiency Syndromes
    1. 42
    2. 5
    3. Pages: 537-544
  4. Type of Article: Article
  5. ISSN: 1525-4135
  1. Abstract:

    Background: The interleukin-7 (IL-7)/IL-7 receptor a (IL-7R alpha) system is an important regulator of T-cell homeostasis. We evaluated the IL-7/IL-7R alpha system in a large cohort of HIV-infected patients, including a subset treated with intermittent IL-2. Methods: IL-7 serum levels and CD127 (IL-7R alpha) expression on T cells were evaluated in a cross-sectional study of 36 healthy volunteers, 151 HIV-infected patients, and 83 HIV-infected patients who had received IL-2 therapy. Multivariate regression models were used to determine predictors of CD127 expression. Results: HIV-infected patients had higher IL-7 levels compared with healthy volunteers (P = 0.022) and IL-2-treated patients (P = 0.012). CD 127 expression was significantly lower on CD4 and CD8 T cells of HIV-infected patients compared with healthy volunteers (P = 0.008 and P < 0.001, respectively), and CD127 median fluorescence intensity was lowest on CD4 T cells in IL-2-treated patients (P < 0.001 compared with HIV-infected patients). The proportion of naive and effector memory/effector T cells were significant predictors of CD127 expression on T cells. IL-2 immunotherapy led to the expansion of a CD25(+)/CD127-low subset of CD4 T cells. Conclusions: CD127 expression on T cells remains low in HIV-infected patients despite antiretroviral therapy, reflecting persistent aberration in the subset composition of the T-cell pool.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000239444100003

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