Skip NavigationSkip to Content
Return Return to Search Results

Design and synthesis of phosphonodifluoromethyl phenylalanine (F(2)Pmp): A useful phosphotyrosyl mimetic

  1. Author:
    Burke, T. R.

  2. Author Address

    NCI, Lab Med Chem, Ctr Canc Res, NIH, Frederick, MD 21702 USA.;Burke, TR, NCI, Lab Med Chem, Ctr Canc Res, NIH, POB B,Bldg 376 Boyles St, Frederick, MD 21702 USA.;tburke@helix.nih.gov
    1. Year: 2006
  2. Journal: Current Topics in Medicinal Chemistry
    1. 6
    2. 14
    3. Pages: 1465-1471
  4. Type of Article: Review
  5. ISSN: 1568-0266
  1. Abstract:

    Hydrolytically-stable phosphotyrosyl (pTyr) mimetics can be useful tools for the study of cellular signal transduction processes. Among pTyr mimetics reported to date, phosphono(diflouromethyl)phenylalanine (F(2)Pmp) has shown particular utility when dealing with protein-tyrosine phosphatases (PTPs). The current overview presents the development of F2Pmp and a summary of approaches toward its synthesis and use.

    See More

  1. Keywords:

External Sources

  1. View record in Web of Science®
  2. WOS: 000240204400004

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel