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Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection

  1. Author:
    Streeck, H.
    Jessen, H.
    Alter, G.
    Teigen, N.
    Waring, M. T.
    Jessen, A.
    Stahmer, I.
    van Lunzen, J.
    Lichterfeld, M.
    Gao, X. J.
    Allen, T. M.
    Carrington, M.
    Walker, B. D.
    Rockstroh, J. K.
    Altfeld, M.

  2. Author Address

    Massachusetts Gen Hosp, Partners AIDS Res Ctr, Infect Dis Unit, Boston, MA 02129 USA. Massachusetts Gen Hosp, Howard Hughes Med Inst, Boston, MA 02129 USA. Harvard Univ, Sch Med, Div Aids, Boston, MA 02115 USA. NCI, Basic Res Program, Sci Applicat Int Corp, Lab Genom Divers, Frederick, MD 21701 USA. Univ Hamburg, Hosp Eppendorf, Med Ctr, Infect Dis Unit, D-20246 Hamburg, Germany. Univ Bonn, Dept Internal Med, Bonn, Germany.;Altfeld, M, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Infect Dis Unit, Bldg 149,13th St,6th Floor, Boston, MA 02129 USA.;maltfeld@partners.org
    1. Year: 2006
    2. Date: Sep
  2. Journal: Journal of Infectious Diseases
    1. 194
    2. 6
    3. Pages: 734-739
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    The immunological and virological impact of short-term treatment initiated during acute human immunodeficiency virus type 1 (HIV-1) infection was assessed prospectively in 20 subjects, 12 of whom initiated highly active antiretroviral therapy (HAART) for 24 weeks and then terminated treatment. Treatment resulted in suppression of viremia, an increase in the CD4(+) T cell count, enhanced differentiation of HIV-1-specific CD8(+) T cells from effector memory to effector cells at week 24 of HAART, and significantly higher virus-specific interferon-gamma(+) CD8(+) T cell responses after viral rebound (at week 48). However, despite these immunological changes, no differences in viremia or in the CD4(+) T cell count were found 6 months after HAART was stopped, when treated subjects were compared with untreated subjects.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000240316600003

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