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Fra-1 a target for cancer prevention or intervention

  1. Author:
    Young, M. R.
    Colburn, N. H.

  2. Author Address

    NCI Frederick, Lab Canc Prevent, Frederick, MD 21702 USA.;Young, MR, NCI Frederick, Lab Canc Prevent, Frederick, MD 21702 USA.;youngm@ncifcrf.gov
    1. Year: 2006
    2. Date: Sep
  2. Journal: Gene
    1. 379
    2. Pages: 1-11
  4. Type of Article: Review
  5. ISSN: 0378-1119
  1. Abstract:

    The transcription factor activator protein-1 (AP-1) has been implicated as a driver of carcinogenesis since its original characterization. Oncogenic transcription factors like AP-1 are becoming new targets for cancer intervention. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. The Fos related antigen-1 (Fra-1) is activated in multiple cancers and gene ablation can suppress the invasive phenotypes of many tumor cell lines. This review focuses on the regulation of fosII expression, stabilization and activation of the Fra-1 polypeptide and on Fra-1-mediated tumorigenesis. Published by Elsevier B.V.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.gene.2006.05.001
  3. View record in Web of Science®
  4. WOS: 000240695500001

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