Skip NavigationSkip to Content
Return Return to Search Results

The Drosophila homolog of the human tumor suppressor gene BHD interacts with the JAK-STAT and Dpp signaling pathways in regulating male germline stem cell maintenance

  1. Author:
    Singh, S. R.
    Zhen, W.
    Zheng, Z.
    Wang, H.
    Oh, S. W.
    Liu, W.
    Zbar, B.
    Schmidt, L. S.
    Hou, S. X.

  2. Author Address

    NCI, Mouse Canc Genet Program, NIH, Frederick, MD 21702 USA. NCI, Immunobiol Lab, NIH, Frederick, MD 21702 USA. NCI, Basic Res Program, SAIC Frederick Inc, Frederick, MD 21702 USA.;Singh, SR, NCI, Mouse Canc Genet Program, NIH, Frederick, MD 21702 USA.;sshreeram@ncifcrf.gov shou@mail.ncifcrf.gov
    1. Year: 2006
    2. Date: Sep
  2. Journal: Oncogene
    1. 25
    2. 44
    3. Pages: 5933-5941
  4. Type of Article: Article
  5. ISSN: 0950-9232
  1. Abstract:

    Birt-Hogg-Dube syndrome (BHD) is a rare, inherited genodermatosis characterized by hair follicle hamartomas, kidney tumors and spontaneous pneumothorax. The BHD locus was mapped to chromosome 17p11.2 by linkage analysis, and germ line mutations in a novel gene ( BHD) were identified in a panel of BHD families. Using RNA interference to decrease expression of the Drosophila BHD homolog (DBHD), we have demonstrated that DBHD is required for male germline stem cell (GSC) maintenance in the fly testis. Reduction of DBHD gene activity suppresses the GSC overproliferation phenotype associated with overexpression of either unpaired (upd) or decapentaplegic (dpp). Further genetic interaction experiments suggest that DBHD regulates GSC maintenance downstream or in parallel of the JAK/STAT and Dpp signal-transduction pathways. These findings suggest that the BHD protein may regulate tumorigenesis through modulating stem cells in human.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1038/sj.onc.1209593
  3. View record in Web of Science®
  4. WOS: 000240826300002

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel