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A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance

  1. Author:
    Allikmets, R.
    Schriml, L. M.
    Hutchinson, A.
    Romano-Spica, V.
    Dean, M.

  2. Author Address

    Dean M NCI, Frederick Canc Res & Dev Ctr, Sci Applicat Int Corp, Intramural Res Support Program Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Sci Applicat Int Corp, Intramural Res Support Program Frederick, MD 21702 USA NCI, Lab Genom Diversity Frederick, MD 21702 USA Catholic Univ Sacred Heart, Fac Med, Inst Hyg & Publ Hlth I-00168 Rome Italy
    1. Year: 1998
  2. Journal: Cancer Research
    1. 58
    2. 23
    3. Pages: 5337-5339
  4. Type of Article: Article
  1. Abstract:

    We characterized a new human ATP-binding cassette (ABC) transporter gene that is highly expressed in the placenta. The gene, ABCP, produces two transcripts that differ at the 5' end and encode the same 655-amino acid protein. The predicted protein is closely related to the Drosophila white and yeast ADP1 genes and is a member of a subfamily that includes several multidrug resistance transporters. ABCP, white, and ADP1 all have a single ATP-binding domain at the NH, terminus and a single COOH-terminal set of transmembrane segments. ABCP maps to human chromosome 4q22, between the markers D4S2462 and D4S1557, and the murine gene (Abcp) is located on chromosome 6 28-29 cM from the centromere, ABCP defines a new syntenic segment between human chromosome 4 and mouse chromosome 6, The abundant expression of this gene in the placenta suggests that the protein product has an important role in transport of specific molecule(s) into or out of this tissue. [References: 25]

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