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The triphosphate of beta-D-4 '-C-ethynyl-2 ',3 '-dideoxycytidine is the preferred enantiomer substrate for HIV reverse transcriptase

  1. Author:
    Siddiqui, M. A.
    Marquez, V. E.

  2. Author Address

    NCI, Med Chem Lab, Canc Res Ctr, Frederick, MD 21702 USA.;Marquez, VE, NCI, Med Chem Lab, Canc Res Ctr, Frederick, MD 21702 USA.;marquezv@dc37a.nci.nih.gov
    1. Year: 2007
    2. Date: Jan
  2. Journal: Bioorganic & Medicinal Chemistry
    1. 15
    2. 1
    3. Pages: 283-287
  4. Type of Article: Article
  5. ISSN: 0968-0896
  1. Abstract:

    The enantioselective synthesis of the beta-D (1) enantiomer of 4-C-ethynyl-2',3'-dideoxycytidine confirms an earlier stereochemical assignment that was strictly based on the ability of HIV reverse transcriptase and its M184V mutant to discriminate between the D- and L-configuration of nucleoside 5'-triphosphates. (c) 2006 Elsevier Ltd. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.bmc.2006.09.061
  3. View record in Web of Science®
  4. WOS: 000243087200026

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