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Identification of the genes for kidney cancer: Opportunity for disease-specific targeted therapeutics

  1. Author:
    Linehan, W. M.
    Pinto, P. A.
    Srinivasan, R.
    Merino, M.
    Choyke, P.
    Choyke, L.
    Coleman, J.
    Toro, J.
    Glenn, G.
    Vocke, C.
    Zbar, B.
    Schmidt, L. S.
    Bottaro, D.
    Neckers, L.

  2. Author Address

    NCI, Urol Oncol Branch, Bethesda, MD 20892 USA. NCI, Pathol Lab, Bethesda, MD 20892 USA. NCI, Mol Imaging Program, Ctr Canc Res, Bethesda, MD 20892 USA. NCI, Genet Epidemiol Branch, Bethesda, MD 20892 USA. NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. NCI, Basic Res Program, Sci Applicat Int Corp, Frederick Inc, Frederick, MD 21701 USA.;Linehan, WM, NCI, Urol Oncol Branch, Room 1-5940,Bldg 10, Bethesda, MD 20892 USA.;wml@nih.gov
    1. Year: 2007
    2. Date: Jan
  2. Journal: Clinical Cancer Research
    1. 13
    2. 2
    3. Pages: 671S-679S
  4. Type of Article: Article
  5. ISSN: 1078-0432
  1. Abstract:

    Recent advances in understanding the kidney cancer gene pathways has provided the foundation for the development of targeted therapeutic approaches for patients with this disease. Kidney cancer is not a single disease; it includes a number of different types of renal cancers, each with different histologic features, a different clinical course, a different response to therapy, and different genes causing the defects. Most of what is known about the genetic basis of kidney cancer has been learned from study of the inherited forms of kidney cancer: von Hippel Lindau (VHL gene), hereditary papillary renal carcinoma (c-Met gene), Birt Hogg Dube (BHD gene), and hereditary leiomyomatosis renal cell cancer (fumarate hydratase gene). These Mendelian single-gene syndromes provide a unique opportunity to evaluate the effectiveness of agents that target the VHL, c-Met, BHD, and fumarate hydratase pathways.

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External Sources

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  2. DOI: 10.1158/1078-0432.ccr-06-1870
  3. View record in Web of Science®
  4. WOS: 000244043600002

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