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Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series

  1. Author:
    Mente, N. R.
    Wiemer, A. J.
    Neighbors, J. D.
    Beutler, J. A.
    Hohl, R. J.
    Wiemer, D. F.

  2. Author Address

    Univ Iowa, Dept Chem, Iowa City, IA 52242 USA. Univ Iowa, Mol & Cellular Biol Program, Iowa City, IA 52242 USA. Univ Iowa, Dept Pharmacol, Iowa City, IA 52242 USA. Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA. NCI, Mol targets Dev Program, Canc Res Ctr, Frederick, MD 21702 USA.;Wiemer, DF, Univ Iowa, Dept Chem, Iowa City, IA 52242 USA.;david-wiemer@uiowa.edu
    1. Year: 2007
    2. Date: Feb
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 17
    2. 4
    3. Pages: 911-915
  4. Type of Article: Article
  5. ISSN: 0960-894X
  1. Abstract:

    Total synthesis of the (R,R,R)- and (S,S,S)-enantiomers of the natural product schweinfurthin F has been completed. Comparisons of spectral data and optical rotations with those reported for the natural product, as well as a variety of bioassay data, allow assignment of the natural material as the (R,R,R)-isomer. (c) 2006 Elsevier Ltd. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.bmcl.2006.11.096
  3. View record in Web of Science®
  4. WOS: 000244636700010

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