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Taxoids: Cancer-fighting compounds from nature

  1. Author:
    Kingston, D. G. I.
    Newman, D. J.

  2. Author Address

    Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA. NCI, Frederick Nat Prod Branch, Frederick, MD 21702 USA.;Kingston, DGI, Virginia Polytech Inst & State Univ, Dept Chem, MC 0212, Blacksburg, VA 24061 USA.;dkingston@vt.edu newmand@mail.nih.gov
    1. Year: 2007
    2. Date: Mar
  2. Journal: Current Opinion in Drug Discovery & Development
    1. 10
    2. 2
    3. Pages: 130-144
  4. Type of Article: Review
  5. ISSN: 1367-6733
  1. Abstract:

    This review covers advances in the discovery, preclinical and clinical development of potential anticancer agents based upon the diterpenoid taxane skeleton. The anticancer properties of approved clinical agents of this class are not discussed, but the review documents how, 13 years post-approval of paclitaxel (Taxol.), the base taxane structure is still utilized as the starting skeleton for molecules with improved pharmacological and toxicological properties. Paclitaxel may in fact be the first example of a 'tunable' anticancer agent. In addition, paclitaxel, and perhaps other taxanes in due course, has activities beyond the known antitumor indications, with an example being the use of paclitaxel-coated stents in cardiovascular therapies.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000244858400003

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