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Synthesis and biological activity of 5-aza-ellipticine derivatives

  1. Author:
    Moody, D. L.
    Dyba, M.
    Kosakowska-Cholody, T.
    Tarasova, N. I.
    Michejda, C. I.

  2. Author Address

    NCI, Struct Biophys Lab, Mol Aspects Drug Design Sect, Struct Biophys Lab, Frederick, MD 21702 USA.;Tarasova, NI, NCI, Struct Biophys Lab, Mol Aspects Drug Design Sect, Struct Biophys Lab, POB B, Frederick, MD 21702 USA.;tarasova@ncifcrf.gov
    1. Year: 2007
    2. Date: Apr
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 17
    2. 8
    3. Pages: 2380-2384
  4. Type of Article: Article
  5. ISSN: 0960-894X
  1. Abstract:

    Novel 5-aza-ellipticine derivatives were synthesized and tested as antitumor agents. The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active as their corresponding ellipticine analogues, the new compounds represent a new, readily accessible class of heteroaromatic catalytic inhibitors of topoisomerase 11 and possible anti-tumor agents. (c) 2006 Elsevier Ltd. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.bmcl.2006.09.093
  3. View record in Web of Science®
  4. WOS: 000246045900054

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