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Histoplasmosis-associated cross-reactivity in the BioRad Platelia Aspergillus enzyme immunoassay

  1. Author:
    Wheat, L. J.
    Hackett, E.
    Durkin, M.
    Connolly, P.
    Petraitiene, R.
    Walsh, T. J.
    Knox, K.
    Hage, C.
  2. Author Address

    MiraVista Diagnost, Indianapolis, IN 46241 USA. NCI, CRC, Pediat Oncol Branch, Immunocompromised Host Sect, Bethesda, MD 20892 USA. SAIC Frederick Inc, Lab Anim Sci Program, Frederick, MD 21702 USA. Indiana Univ, Sch Med, Dept Pulm Med, Roudebush Vet Adm Hosp, Indianapolis, IN 46202 USA.;Wheat, LJ, MiraVista Diagnost, 4444 Decatur Blvd,Suite 300, Indianapolis, IN 46241 USA.;jwheat@miravistalabs.com
    1. Year: 2007
    2. Date: May
  1. Journal: Clinical and Vaccine Immunology
    1. 14
    2. 5
    3. Pages: 638-640
  2. Type of Article: Article
  3. ISSN: 1556-6811
  1. Abstract:

    We observed false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA) for specimens from patients with histoplasmosis and mice with experimental infection. Platelia Aspergillus EIA-positive specimens were negative in the second-generation Histoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive Platelia Aspergillus EIA results.

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External Sources

  1. DOI: 10.1128/cvi.00479-06
  2. WOS: 000246681800022

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