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The Novel Atm-Related Protein Trrap Is an Essential Cofactor For the C-Myc and E2f Oncoproteins

  1. Author:
    McMahon, S. B.
    Vanbuskirk, H. A.
    Dugan, K. A.
    Copeland, T. D.
    Cole, M. D.
    1. Year: 1998
  2. Journal: Cell
    1. 94
    2. 3
    3. Pages: 363-374
  4. Type of Article: Article
  1. Abstract:

    The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle progression in higher eukaryotes. This report describes the isolation of a novel, highly conserved 434 kDa protein, designated TRRAP, which interacts specifically with the c-Myc N terminus and has homology to the ATM/PI3- kinase family. TRRAP also interacts specifically with the E2F-1 transactivation domain. Expression of transdominant mutants of the TRRAP protein or antisense RNA blocks c-Myc- and E1A-mediated oncogenic transformation. These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways. [References: 52]

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