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CITED1 expression in Wilms' tumor and embryonic kidney

  1. Author:
    Lovvorn, H. N.
    Westrup, J.
    Opperman, S.
    Boyle, S.
    Shi, G.
    Anderson, J.
    Perlman, E. J.
    Perantoni, A. O.
    Wills, M.
    de Caestecker, M.

  2. Author Address

    Vanderbilt Univ, Sch Med, Dept Pediat Surg, Nashville, TN 37212 USA. Vanderbilt Univ, Sch Med, Div Nephrol & Cell & Dev Biol, Nashville, TN 37212 USA. Univ Nebraska Med Ctr, Omaha, NE 68198 USA. Northwestern Univ, Dept Pathol, Chicago, IL 60611 USA. Natl Canc Inst, Lab Comparat Carcinogenesis, Frederick, MD USA. Vanderbilt Univ, Sch Med, Sect Pediat Pathol, Nashville, TN 37212 USA.;Lovvorn, HN, Suite 4150,2200 Childrens Way, Nashville, TN 37232 USA.;harold.lovvorn@vanderbilt.edu
    1. Year: 2007
    2. Date: Jul
  2. Journal: Neoplasia
    1. 9
    2. 7
    3. Pages: 589-600
  4. Type of Article: Article
  5. ISSN: 1522-8002
  1. Abstract:

    Wilms' tumors, or nephroblastomas, are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed metanephric mesenchyme within embryonic kidneys. We have previously shown that the transcriptional regulator CITED1 (CBP/ p300 -interacting transactivators with glutamic acid [E]/ aspartic acid [D]-rich C-terminal domain) is expressed exclusively in these nephrogenic progenitor cells and is downregulated as they differentiate to form nephronic epithelia. In the current study, we show that CITED1 expression persists in blastemal cell populations of both experimental rat nephroblastomas and human Wilms' tumors, and that primary human Wilms' tumors presenting with disseminated disease show the highest level of CITED1 expression. Unlike the predominantly cytoplasmic subcellular localization of CITED1 in the normal developing kidney, CITED1 is clearly detectable in the nuclear compartment of Wilms' tumor blastema. These findings indicate that CITED1 is a marker of primitive blastema in Wilms' tumors and suggest that persistent expression and/ or altered subcellular localization of CITED1 in the condensed metanephric mesenchyme could play a role in Wilms' tumor initiation and pathogenesis.

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  2. DOI: 10.1593/neo.07358
  3. View record in Web of Science®
  4. WOS: 000248495100008

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