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Mamu-B*08-positive macaques control simian immunodeficiency virus replication

  1. Author:
    Loffredo, J. T.
    Maxwell, J.
    Qi, Y.
    Glidden, C. E.
    Borchardt, G. J.
    Soma, T.
    Bean, A. T.
    Beal, D. R.
    Wilson, N. A.
    Rehrauer, W. M.
    Lifson, J. D.
    Carrington, M.
    Watkins, D. I.

  2. Author Address

    Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI 53715 USA. NCI, Lab Genom Divers, SAIC Frederick Inc, Frederick, MD 21702 USA. NCI, AIDS Vaccine Program, Basic Res Program, SAIC Frederick Inc, Frederick, MD 21702 USA.;Watkins, DI, Univ Wisconsin, Dept Pathol & Lab Med, 555 Sci Dr, Madison, WI 53711 USA.;watkins@primate.wisc.edu
    1. Year: 2007
    2. Date: Aug
  2. Journal: Journal of Virology
    1. 81
    2. 16
    3. Pages: 8827-8832
  4. Type of Article: Article
  5. ISSN: 0022-538X
  1. Abstract:

    Certain major histocompatibillity complex (MHC) class I allelles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIVmac,239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.

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External Sources

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  2. DOI: 10.1128/jvi.00895-07
  3. View record in Web of Science®
  4. WOS: 000248649100046

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