Skip NavigationSkip to Content
Return Return to Search Results

Splenic CD19(-)CD35(+)B220(+) cells function as an inducer of follicular dendritic cell network formation

  1. Author:
    Murakami, T.
    Chen, X.
    Hase, K.
    Sakamoto, A.
    Nishigaki, C.
    Ohno, H.

  2. Author Address

    RIKEN, Res Ctr Allergy & Immunol, Lab Epithelial Immunobiol, Yokohama, Kanagawa, Japan. NCI, SAIC, Lab Mol Immunoregulat, Basic Res Program, Frederick, MD USA. Yokohama City Univ, Int Grad Sch Arts & Sci, Yokohama, Kanagawa 232, Japan.;Ohno, H, RIKEN, Res Ctr Allergy & Immunol, Lab Epithelial Immunobiol, Yokohama, Kanagawa, Japan.;ohno@rcai.riken.jp
    1. Year: 2007
    2. Date: Aug
  2. Journal: Blood
    1. 110
    2. 4
    3. Pages: 1215-1224
  4. Type of Article: Article
  5. ISSN: 0006-4971
  1. Abstract:

    Follicular dendritic cells (FDCs) form a reticular FDC network in the lymphoid follicle that is essential for the retention and presentation of native antigens in the form of antigen-antibody immune complexes (ICs) to B cells during secondary immune response. Although the presence of migrating precursors of FDCs has been hypothesized, their entity has not been elucidated. Here we report the identification of murine splenic CD19(-)CD11c(-)CD35(+)B220(+) cells as an inducer of FDC network formation. We demonstrated that CD19(-)CD11c(-)CD35(+)B220(+) cells, together with stromal cells, had the remarkable ability to form lymphold-follicle-like structures that contained B220(+)FDC(-)M1(+) reticular cells originally derived from CD19(-)CD11c(-)CD35(+)B220(+) cells in the CD35(+) reticulum. Our results indicate that CD19(-)CD11c(-)CD35(+)B220(+) cells function as an inducer of FDC network formation and that the interaction between CD19(-)CD11c(-)CD35(+)B220(+) cells and stromal cells is required to initiate lymphoid follicle formation.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1182/blood-2007-01-068387
  3. View record in Web of Science®
  4. WOS: 000248655300026

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel