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Cytokine and chemokine profiles following vaccination with human papillomavirus type 16 L1 virus-like particles

  1. Author:
    Garcia-Pineres, A.
    Hildesheim, A.
    Dodd, L.
    Kemp, T. J.
    Williams, M.
    Harro, C.
    Lowy, D. R.
    Schiller, J. T.
    Pinto, L. A.

  2. Author Address

    NCI Frederick, Frederick, MD 21702 USA. SAIC Frederick Inc, HPV Immunol Lab, Frederick, MD USA. Natl Inst Hlth, Div Canc Epidemiol & Genet, Bethesda, MD USA. Natl Inst Hlth, Div Canc Treatment & Diagnosis, Biometr Res Branch, Bethesda, MD USA. Johns Hopkins Univ, Baltimore, MD USA. Natl Inst Hlth, Ctr Canc Res, Bethesda, MD USA.;Pinto, LA, NCI Frederick, Bldg 469,Room 120, Frederick, MD 21702 USA.;lpinto@ncifcrf.gov
    1. Year: 2007
    2. Date: Aug
  2. Journal: Clinical and Vaccine Immunology
    1. 14
    2. 8
    3. Pages: 984-989
  4. Type of Article: Article
  5. ISSN: 1556-6811
  1. Abstract:

    To determine the systemic cytokine pattern induced by vaccination with human papillomavirus (HPV) L1 virus-like particles (VLP), we analyzed 22 different cytokines in culture supernatants of Ll VLP-stimulated peripheral blood mononuclear cells from vaccine (n = 19) and placebo (n = 7) recipients at months 0 and 2 after vaccination, using a multiplex cytokine bead array. In vaccine recipients, incubation with Ll VLP in vitro led to a statistically significant increase in production of Th1 (granulocyte-macrophage colony-stimulating factor, interleukin-2 [IL-2], gamma interferon; P < 0.0007) and Th2 (IL-4, IL-5, IL-10, IL-13; P < 0.0017) cytokines and the chemokine IP-10 (P = 0.0021) at month 2 after immunization, compared to levels seen prior to vaccination. These responses were not seen in placebo recipients. Cytokine and neutralizing antibody responses to vaccination followed the same pattern, with the highest antibody responses seen for subjects with higher cytokine responses. Cytokine profiling studies using samples from efficacy trials may provide important information about discriminators of long-term protection against HPV.

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External Sources

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  2. DOI: 10.1128/cvi.00090-07
  3. View record in Web of Science®
  4. WOS: 000248796100008

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