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Nitric oxide prodrugs: Diazeniumdiolate anions of hindered secondary Amines

  1. Author:
    Chakrapani, H.
    Showalter, B. M.
    Citro, M. L.
    Keefer, L. K.
    Saavedra, J. E.

  2. Author Address

    Natl Canc Inst, Comparat Carcinogenesis Lab, Chem Sect, Ft Detrick, MD 21702 USA. Natl Canc Inst, SAIC Frederick, Basic Res Program, Ft Detrick, MD 21702 USA.;Chakrapani, H, Natl Canc Inst, Comparat Carcinogenesis Lab, Chem Sect, Ft Detrick, MD 21702 USA.;chakrah@ncifcrf.gov saavj@ncifcrf.gov
    1. Year: 2007
    2. Date: Oct
  2. Journal: Organic Letters
    1. 9
    2. 22
    3. Pages: 4551-4554
  4. Type of Article: Article
  5. ISSN: 1523-7060
  1. Abstract:

    [GRAPHICS] Nitric oxide prodrugs derived from hindered secondary amines were prepared. The decomposition patterns of these prodrugs indicate that alpha-methyl groups around the nitrogen bearing the diazeniumdiolate group prolong their half-life in aqueous buffer.

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External Sources

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  2. DOI: 10.1021/o17019636
  3. View record in Web of Science®
  4. WOS: 000250302000038

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