Skip NavigationSkip to Content
Return Return to Search Results

An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis

  1. Author:
    Takada, K.
    Bermingham, A.
    O'Keefe, B. R.
    Wamiru, A.
    Beutler, J. A.
    Le Grice, S. F. J.
    Lloyd, J.
    Gustafson, K. R.
    McMahon, J. B.

  2. Author Address

    NCI, Ctr Canc Res, Mol Targets Dev Programs, Ft Detrick, MD 21702 USA. SAIC Frederick Inc, Basic Res Program, Frederick, MD USA. NCI, CCR, Drug Resistance Program, Ft Detrick, MD 21702 USA. NIDDK, Protemoics & Mass Spectrometry Fac, Bethesda, MD USA.;Gustafson, KR, NCI, Ctr Canc Res, Mol Targets Dev Programs, Bldg 1052,Room 121, Ft Detrick, MD 21702 USA.;gustafson@ncifcrf.gov
    1. Year: 2007
    2. Date: Oct
  2. Journal: Journal of Natural Products
    1. 70
    2. 10
    3. Pages: 1647-1649
  4. Type of Article: Article
  5. ISSN: 0163-3864
  1. Abstract:

    A new compound, 1,3,4,5-tetragalloylapiitol (1), was isolated from the aqueous extract of the plant Hylodendron gabunensis and was found to be a potent inhibitor of RNase H enzymatic activity. The structure of 1 was elucidated by NMR analyses to be an apiitol (2) sugar moiety substituted with four gallic acid residues. Optical rotation measurements of the free sugar following basic hydrolysis indicated that the 3S absolute configuration was the same as that Of D-apiitol. Compound I inhibited HIV-1, HIV-2, and human RNase H with IC50 values of 0.24, 0.13, and 1.5 mu M, respectively, but it did not show inhibition of E. coli RNase H at 10 mu M.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1021/np0702279
  3. View record in Web of Science®
  4. WOS: 000250555700021

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel