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Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage

  1. Author:
    Lo, P. H. Y.
    Xie, D.
    Chan, K. C.
    Xu, F. P.
    Kuzmin, I.
    Lerman, M. I.
    Law, S.
    Chua, D.
    Sham, J.
    Lung, M. L.

  2. Author Address

    Hong Kong Univ Sci & Technol, Canc Res Ctr, Dept Biol, Hong Kong, Peoples R China. Sun Yat Sen Univ, Ctr Canc, State Key Lab Onc So China, Guangzhou, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pathol, Guangzhou, Peoples R China. Sci Applicat Int Corp Frederick Inc, Natl Canc Inst, Basic Res Program, Frederick, MD USA. Natl Canc Inst, Ctr Canc Res, Immunobiol Lab, Canc Causing Genes Sect, Frederick, MD USA. Univ Hong Kong, Dept Surg, Hong Kong, Peoples R China. Univ Hong Kong, Dept Clin Oncol, Hong Kong, Peoples R China.;Lung, ML, Hong Kong Univ Sci & Technol, Canc Res Ctr, Dept Biol, Hong Kong, Peoples R China.;bomaria@ust.hk
    1. Year: 2007
    2. Date: Nov
  2. Journal: Cancer Letters
    1. 257
    2. 2
    3. Pages: 199-205
  4. Type of Article: Article
  5. ISSN: 0304-3835
  1. Abstract:

    Reduced expression or loss of tumor suppressor genes play a key role in many cancers. In this study, we investigated the role of RASSF1A in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). We detected the down-regulated expression of both RASSF1A transcripts and protein in tumor tissues using RT-PCR and tissue microarray immunohistochemical staining analyses. Down-regulated expression of RASSF1A showed a significant association with WHO grade, tumor status, and lymph node metastasis, showing its possible utility as a biomarker for clinical specimens. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.canlet.2007.07.018
  3. View record in Web of Science®
  4. WOS: 000250912100007

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