Skip NavigationSkip to Content
Return Return to Search Results

HIV-1 envelope protein binds to and signals through integrin alpha(4)beta(7), the gut mucosal homing receptor for peripheral T cells

  1. Author:
    Arthos, J.
    Cicala, C.
    Martinelli, E.
    Macleod, K.
    Van Ryk, D.
    Wei, D.
    Xiao, Z.
    Veenstra, T. D.
    Conrad, T. P.
    Lempicki, R. A.
    McLaughlin, S.
    Pascuccio, M.
    Gopaul, R.
    McNally, J.
    Cruz, C. C.
    Censoplano, N.
    Chung, E.
    Reitano, K. N.

  2. Author Address

    Arthos, James, Cicala, Claudia, Macleod, Katilyn, Van Ryk, Donald, Wei, Danlan, Pascuccio, Massimiliano, Gopaul, Ravindra, McNally, Jonathan, Cruz, Catherine C.; Censoplano, Nina, Chung, Eva, Reitano, Kristin N.; Kottilil, Shyam, Goode, Diana J.; Fauci, Anthony S.] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [Martinelli, Elena] Univ Genoa, Ctr Excellence Biomed Res, Genoa, Italy. [Xiao, Zhen, Veenstra, Timothy D.; Conrad, Thomas P.] Sci Applicat Int Corp, Lab Proteom & Analyt Technol, Frederick, MD 21702 USA. [Lempicki, Richard A.] Sci Applicat Int Corp, Lab Immunopathogenesis & Bioinformat, Frederick, MD 21702 USA. [McLaughlin, Sherry] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA.
    1. Year: 2008
  2. Journal: Nature Immunology
    1. 9
    2. 3
    3. Pages: 301-309
  4. Type of Article: Article
  1. Abstract:

    Infection with human immunodeficiency virus 1 (HIV-1) results in the dissemination of virus to gut-associated lymphoid tissue. Subsequently, HIV-1 mediates massive depletion of gut CD4(+) T cells, which contributes to HIV-1-induced immune dysfunction. The migration of lymphocytes to gut-associated lymphoid tissue is mediated by integrin alpha(4)beta(7). We demonstrate here that the HIV-1 envelope protein gp120 bound to an activated form of alpha(4)beta(7). This interaction was mediated by a tripeptide in the V2 loop of gp120, a peptide motif that mimics structures presented by the natural ligands of alpha(4)beta(7). On CD4(+) T cells, engagement of alpha(4)beta(7) by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1.

    See More

  1. Keywords:

External Sources

  1. PMID: 18264102

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel