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Rab22 and Rab163/Mouse Brca2 - Proteins That Specifically Interact With the Rad51 Protein

  1. Author:
    Mizuta, R.
    Lasalle, J. M.
    Cheng, H. L.
    Shinohara, A.
    Ogawa, H.
    Copeland, N.
    Jenkins, N. A.
    Lalande, M.
    Alt, F. W.

  2. Author Address

    Alt FW CHILDRENS HOSP HOWARD HUGHES MED INST 300 LONGWOOD AVE BOSTON, MA 02115 USA CHILDRENS HOSP HOWARD HUGHES MED INST BOSTON, MA 02115 USA HARVARD UNIV SCH MED DEPT GENET BOSTON, MA 02115 USA HARVARD UNIV SCH MED CTR BLOOD RES BOSTON, MA 02115 USA OSAKA UNIV FAC SCI DEPT BIOL TOYONAKA OSAKA 560 JAPAN NCI FREDERICK CANC RES & DEV CTR MAMMALIAN GENET LAB ABL BASIC RES PROGRAM NIH FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 94
    2. 13
    3. Pages: 6927-6932
  4. Type of Article: Article
  1. Abstract:

    The human RAD51 protein is a homologue of the bacteria RecA and yeast RAD51 proteins that are involved in homologous recombination and DNA repair, RAD51 interacts with proteins involved in recombination and also with tumor suppressor proteins p53 and breast cancer susceptibility gene 1 (BRCA1), We have used the yeast two-hybrid system to clone murine cDNA sequences that encode two RAD51-associated molecules, RAB22 and RAB163. RAB163 encodes the C-terminal portion of mouse BRCA2, the homologue of the second breast cancer susceptibility gene protein in humans, demonstrating an in vitro association between RAD51 and BRCA2, RAB22 is a novel gene product that also interacts with RAD51 bl vitro, To detect RAD51 interactions in vivo, we developed a transient nuclear focus assay that was used to demonstrate a complete colocalization of RAB22 with RAD51 in large nuclear foci. [References: 35]

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