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A dual CT-MR dendrimer contrast agent as a surrogate marker for convection-enhanced delivery of intracerebral macromolecular therapeutic agents

  1. Author:
    Regino, C.
    Walbridge, S.
    Bernardo, M.
    Wong, K. J.
    Johnson, D.
    Lonser, R.
    Oldfield, E. H.
    Choyke, P. L.
    Brechbiel, M. W.

  2. Author Address

    Regino, Celeste Aida S.; Brechbiel, Martin W.] NCI, Radiat Oncol Branch, Radioimmune & Inorgan Chem Sect, NIH, Bethesda, MD 20892 USA. [Walbridge, Stuart, Lonser, Russell, Oldfield, Edward H.] NINDS, Clin Neurosurg Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA. [Bernardo, Marcelino] SAIC Frederick Inc, Lab Anim Sci Program, NCI Frederick, Imaging Phys, Frederick, MD 21702 USA. [Bernardo, Marcelino, Wong, Karen J.; Choyke, Peter L.] NCI, Mol Imaging Program, NIH, Bethesda, MD 20892 USA. [Johnson, Dennis] NIH, NIH Clin Ctr, Dept Diagnost Radiol, Bethesda, MD 20892 USA.
    1. Year: 2008
  2. Journal: Contrast Media & Molecular Imaging
    1. 3
    2. 1
    3. Pages: 2-8
  4. Type of Article: Article
  1. Abstract:

    The feasibility of using Gd dendrimer-based macromolecules (Gd-G8 dendrimer) as a dual CT and MR contrast agent for monitoring convection-enhanced delivery of therapy in the brain is evaluated both in vitro and in vivo with optimal dosing established. In vitro CT attenuation values of the Gd-based agents (similar to 6.0 HU mm(-1)) were similar to 1.6 times greater than iodine-based agents and the attenuation of the Gd-DTPA was comparable to Gd-G8 dendrimer. Visible enhancement was observed on both CT and MR using Gd-G8 dendrimer over a range of 23-78 mm, however, a concentration of at least 47 mm in Gd was required for adequate delineation of the injection site on both CT and MR. MR offers greater sensitivity than CT in estimating the volume of distribution (V-d) and effectively quantified the agent's concentration and diffusion using T, mapping at much lower concentrations of Gd (< 10 mm in [Gd]). Copyright (c) 2008 John Wiley & Sons, Ltd.

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External Sources

  1. PMID: 18335478

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