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Genetic background and the dilemma of translating mouse studies to humans

  1. Author:
    Rivera, J.
    Tessarollo, L.

  2. Author Address

    Rivera, Juan] NIAMSD, Lab Immune Cell Signalling, NIH, Bethesda, MD 20892 USA. [Tessarollo, Lino] NCI, Canc Res Ctr, Mouse Canc Genet Program, Neural Dev Grp, Frederick, MD 21702 USA.
    1. Year: 2008
  2. Journal: Immunity
    1. 28
    2. 1
    3. Pages: 1-4
  4. Type of Article: Editorial Material
  1. Abstract:

    C57BL/6 genetically modified mouse models are the accepted gold standard in biological studies. However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions.

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  1. Keywords:

External Sources

  1. PMID: 18199409

Library Notes

  1. No notes added.
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