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Peptide Inhibitors of HIV-1 Egress

  1. Author:
    Waheed, A. A.
    Freed, E. O.

  2. Author Address

    Waheed, Abdul A.; Freed, Eric O.] NCI, HIV Drug Resistance Program, Virus Cell Interact Sect, Frederick, MD 21702 USA.
    1. Year: 2008
  2. Journal: Acs Chemical Biology
    1. 3
    2. 12
    3. Pages: 745-747
  4. Type of Article: Article
  1. Abstract:

    HIV-1 release requires a direct interaction between the p6 domain of the Gag protein and Tsg101, a component of the cellular endosomal sorting complex required for transport I (ESCRT-1). Disruption of the binding between Gag and Tsg101 is highly detrimental to particle release, making this viral-host cell interaction a potential target for the development of novel anti-HIV-1 agents. An article in this issue reports on the application of a bacterial reverse two-hybrid strategy to identify a cyclic peptide that disrupts Gag-Tsg101 binding and suppresses HIV-1 particle release.

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External Sources

  1. PMID: 19099395

Library Notes

  1. No notes added.
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