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Glioblastoma stem cells produce vascular endothelial growth factor by activation of a G-protein coupled formylpeptide receptor FPR

  1. Author:
    Yao, X. H.
    Ping, Y. F.
    Chen, J. H.
    Xu, C. P.
    Chen, D. L.
    Zhang, R.
    Wang, J. M.
    Bian, X. W.

  2. Author Address

    Yao, X-H, Ping, Y-F, Chen, J-H, Xu, C-P, Chen, D-L, Zhang, R.; Bian, X-W] Third Mil Med Univ, SW Hosp, Inst Pathol, Chongqing 400038, Peoples R China. [Chen, J-H] Third Mil Med Univ, SW Hosp, Dept Pharm, Chongqing 400038, Peoples R China. [Wang, J. M.] NCI, Mol Immunoregulat Lab, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA.
    1. Year: 2008
  2. Journal: Journal of Pathology
    1. 215
    2. 4
    3. Pages: 369-376
  4. Type of Article: Article
  1. Abstract:

    Glioma stem cells (GSCs), or stem cell-like glioma cells, isolated from malignant glioma cell lines, were capable of producing vascular endothelial growth factor (VEGF). However, the exact role of such tumour cells in angiogenesis remains unknown. In this study, we isolated a small proportion of CD133(+) GSCs from the human glioblastoma cell line U87 and found that these GSCs possessed multipotent differentiation potential and released high levels of VEGF as compared with CD133(-) tumour cells. The CD133(+) GSCs also formed larger xenograft tumours that contained higher VEGF immunoreactivity and denser microvessels. Moreover, GSCs expressed a functional G protein-coupled formylpeptide receptor FPR, which was activated by a chemotactic peptide ligand, N-formylmethionyl-leucyl-phenylaianine (fMLF), to mediate calcium flux and the production of VEGF by GSCs. Our results indicate that FPR expressed by human GSCs may play an important role in glioma angiogenesis. Copyright (c) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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External Sources

  1. PMID: 18523971

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