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A new look at cytokine signaling

  1. Author:
    Zdanov, A.
    Wlodawer, A.

  2. Author Address

    Zdanov, Alexander, Wlodawer, Alexander] NCI, CCR, Macromol Crystallog Lab, Frederick, MD 21702 USA.
    1. Year: 2008
  2. Journal: Cell
    1. 132
    2. 2
    3. Pages: 179-181
  4. Type of Article: Editorial Material
  1. Abstract:

    Signal transduction is initiated when a cytokine binds to the extracellular domains of its receptors, bringing them together and triggering a complicated sequence of events inside the cell. In this issue, LaPorte et al. ( 2008) present crystal structures of three signaling complexes of the cytokines interleukin-4 and interleukin-13 with their receptors, showing how events taking place outside the cell may affect the specificity of signal transduction.

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External Sources

  1. PMID: 18243092

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