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Association of Interleukin-15-Induced Peripheral Immune Activation with Hepatic Stellate Cell Activation in Persons Coinfected with Hepatitis C Virus and HIV

  1. Author:
    Allison, R. D.
    Katsounas, A.
    Koziol, D. E.
    Kleiner, D. E.
    Alter, H. J.
    Lempicki, R. A.
    Wood, B.
    Yang, J.
    Fullmer, B.
    Cortez, K. J.
    Polis, M. A.
    Kottilil, S.

  2. Author Address

    Katsounas, Antonios, Polis, Michael A.; Kottilil, Shyam] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [Allison, Robert D.; Alter, Harvey J.] NIH, Dept Transfus Med, Bethesda, MD 20892 USA. [Kleiner, David E.] NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA. [Wood, Brad] NIH Clin Ctr, Div Radiol, Bethesda, MD USA. [Lempicki, Richard A.; Yang, Jun, Fullmer, Brandie] SAIC Frederick, Frederick, MD USA.
    1. Year: 2009
  2. Journal: Journal of Infectious Diseases
    1. 200
    2. 4
    3. Pages: 619-623
  4. Type of Article: Article
  1. Abstract:

    Hepatic stellate cells (HSCs) mediate hepatitis C virus (HCV)-related liver fibrosis, and increased HSC activation in human immunodeficiency virus (HIV)/HCV coinfection may be associated with accelerated fibrosis. We examined the level of HSC activation in HIV/HCV-coinfected and HCV-monoinfected subjects and its relationship to the level of activation and gene expression of peripheral immune cells in coinfected subjects. HSC activation levels positively correlated with peripheral CD4(+) and CD8(+) T cell immune activation and were associated with enhanced interleukin-15 (IL-15) gene expression, suggesting a pathogenic role for IL-15-driven immunomediated hepatic fibrosis. Future strategies that reduce immune activation and HSC activation may delay progression of liver fibrosis.

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  2. DOI: 10.1086/600107
  3. PMID: 19594300

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