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Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

  1. Author:
    Amundadottir, L.
    Kraft, P.
    Stolzenberg-Solomon, R. Z.
    Fuchs, C. S.
    Petersen, G. M.
    Arslan, A. A.
    Bueno-de-Mesquita, H. B.
    Gross, M.
    Helzlsouer, K.
    Jacobs, E. J.
    LaCroix, A.
    Zheng, W.
    Albanes, D.
    Bamlet, W.
    Berg, C. D.
    Hoover, R.

  2. Author Address

    Amundadottir, Laufey, Chanock, Stephen J.] Natl Canc Inst, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH,Dept Hlt & Human Serv, Bethesda, MD 20892 USA. [Amundadottir, Laufey, Stolzenberg-Solomon, Rachael Z.; Albanes, Demetrius, Hutchinson, Amy, Mendelsohn, Julie B.; Thomas, Gilles, Tobias, Geoffrey S.; Yu, Kai, Chanock, Stephen J.; Hartge, Patricia, Hoover, Robert N.] Natl Canc Inst, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD USA. [Kraft, Peter, Giovannucci, Edward L.; Hankinson, Susan E.; Hunter, David J.; Michaud, Dominique S.; Trichopoulos, Dimitrios] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Fuchs, Charles S.; Wolpin, Brian M.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Fuchs, Charles S.; Giovannucci, Edward L.; Hankinson, Susan E.; Hunter, David J.; Wolpin, Brian M.] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA. [Petersen, Gloria M.; Bamlet, William, de Andrade, Mariza] Mayo Clin, Dept Hlth Sci Res, Coll Med, Rochester, MN USA. [Arslan, Alan A.; Zeleniuch-Jacquotte, Anne] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA. [Arslan, Alan A.] NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA. [Arslan, Alan A.; Zeleniuch-Jacquotte, Anne] NYU, Inst Canc, New York, NY USA. [Bueno-de-Mesquita, H. Bas] Natl Inst Publ Hlth & Environm, RIVM, NL-3720 BA Bilthoven, Netherlands. [Bueno-de-Mesquita, H. Bas] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands. [Gross, Myron] Univ Minnesota, Sch Med, Dept Lab Med Pathol, Minneapolis, MN 55455 USA. [Helzlsouer, Kathy] St Johns Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA. [Jacobs, Eric J.; Patel, Alpa V.] Amer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA. [LaCroix, Andrea, Kooperberg, Charles, Mandelson, Margaret] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA. [Zheng, Wei, Shu, Xiao-Ou] Vanderbilt Univ, Dept Med, Nashville, TN USA. [Zheng, Wei, Shu, Xiao-Ou] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN USA. [Berg, Christine D.] Natl Canc Inst, Canc Prevent Div, NIH, Dept Hlth & Human Serv, Bethesda, MD USA. [Berrino, Franco] Ist Nazl Tumori, Etiol Epidemiol & Prevent Unit, Fdn IRCCS, I-20133 Milan, Italy. [Bingham, Sheila] Univ Cambridge, MRC, Dunn Human Nutr Unit, Cambridge, England. [Buring, Julie E.] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA. [Buring, Julie E.] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA. [Buring, Julie E.] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA USA. [Bracci, Paige M.; Holly, Elizabeth A.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Canzian, Federico, Kaaks, Rudolf] German Canc Res Ctr, Div Canc Epidemiol, DKFZ, D-6900 Heidelberg, Germany. [Clavel-Chapelon, Francoise] INSERM, Villejuif, France. [Clavel-Chapelon, Francoise] Inst Gustave Roussy, Villejuif, France. [Clipp, Sandra] Johns Hopkins Bloomberg Sch Publ Hlth, George W Comstock Ctr Publ Hlth Res & Prevent, Hagerstown, MD USA. [Cotterchio, Michelle] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON M5S 1A1, Canada. [Duell, Eric J.; Jenab, Mazda] Int Agcy Res Canc, F-69372 Lyon, France. [Fox, John W., Jr.] Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA. [Gallinger, Steven] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada. [Gaziano, J. Michael] Brigham & Womens Hosp, Dept Med, Div Cardiovasc Med, Boston, MA 02115 USA. [Gaziano, J. Michael] Vet Affairs Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA. [Giovannucci, Edward L.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Goggins, Michael] Johns Hopkins Univ, Sch Med, Dept Oncol, Sol Goldman Pancreat Res Ctr, Baltimore, MD 21205 USA. [Goggins, Michael] Johns Hopkins Univ, Sch Med, Dept Pathol, Sol Goldman Pancreat Res Ctr, Baltimore, MD 21205 USA. [Goggins, Michael] Johns Hopkins U iv, Sch Med, Dept Med, Sol Goldman Pancreat Res Ctr, Baltimore, MD 21205 USA. [Gonzalez, Carlos A.] ICO, Unit Nutr Environm & Canc, Canc Epidemiol Res Programme, Barcelona, Spain. [Hallmans, Goran] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden. [Hassan, Manal, Li, Donghui] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA. [Hutchinson, Amy, Jacobs, Kevin B.] SAIC Frederick Inc, Core Genotyping Facil, Adv Technol Program, NCI, Frederick, MD USA. [Jackson, Rebecca] Ohio State Univ, Dept Internal Med, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA. [Jackson, Rebecca] Ohio State Univ, Ctr Clin & Translat Sci, Columbus, OH 43210 USA. [Jacobs, Kevin B.] Bioinformed LLC, Gaithersburg, MD USA. [Klein, Alison P.] Johns Hopkins Med Inst, Dept Epidemiol, Johns Hopkins Bloomberg Sch Publ Hlth, Sol Goldman Pancreat Res Ctr, Baltimore, MD 21205 USA. [Lynch, Shannon M.] Natl Canc Inst, Epidemiol & Genet Res Program, Div Canc Control & Populat Sci, NIH,Dept Hlth & Human Serv, Bethesda, MD USA. [Kurtz, Robert C.] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA. [Mandelson, Margaret] Grp Hlth Ctr Hlth Studies, Seattle, WA USA. [McWilliams, Robert R.] Mayo Clin, Dept Oncol, Coll Med, Rochester, MN USA. [Michaud, Dominique S.; Peeters, Petra H. M.; Riboli, Elio] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England. [Olson, Sara H.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA. [Overvad, Kim] Aarhus Univ Hosp, Aalborg Hosp, Dept Cardiol, Aalborg, Denmark. [Overvad, Kim] Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Epidemiol, Aalborg, Denmark. [Peeters, Petra H. M.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [Rajkovic, Aleksandar] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA. [Risch, Harvey A.; Yu, Herbert] Yale Univ, Sch Publ Hlth, New Haven, CT USA. [Trichopoulos, Dimitrios] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece. [Van Den Eeden, Stephen K.] No Calif Reg, Div Res, Kaiser Permanente, Oakland, CA USA. [Virtamo, Jarmo] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland. [Wactawski-Wende, Jean] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
    1. Year: 2009
  2. Journal: Nature Genetics
    1. 41
    2. 9
    3. Pages: 986-U47
  4. Type of Article: Article
  1. Abstract:

    We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based casecontrol study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20, 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

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  2. DOI: 10.1038/ng.429
  3. PMID: 19648918

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