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Differential Effect of Genistein On Transforming Growth Factor Beta-1 Expression in Normal and Malignant Mammary Epithelial Cells

  1. Author:
    Sathyamoorthy, N.
    Gilsdorf, J. S.
    Wang, T. T. Y.
    1. Year: 1998
  2. Journal: Anticancer Research
    1. 18
    2. 4A
    3. Pages: 2449-2453
  4. Type of Article: Article
  1. Abstract:

    Our present study demonstrates that the isoflavone genistein exerts a differential response in normal and malignant breast epithelial cells. The addition of genistein results in a dose-dependent increase in TGF-beta 1 mRNA expression in normal human mammary epithelial cells (HMEC) but not in tumor-derived MCF-7 cells. Genistein inhibits the growth and also causes an increase in apoptosis of HMEC. I;he increased expression of TGF-beta 1 may contribute to the growth inhibitory as well as apoptotic effects of genistein on HMEC. [References: 23]

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