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MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility

  1. Author:
    Fan, H. Y.
    Liu, Z. L.
    Shimada, M.
    Sterneck, E.
    Johnson, P. F.
    Hedrick, S. M.
    Richards, J. S.

  2. Author Address

    Fan, Heng-Yu, Liu, Zhilin, Richards, JoAnne S.] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA. [Shimada, Masayuki] Hiroshima Univ, Grad Sch Biosphere Sci, Dept Appl Anim Sci, Higashihiroshima 7398528, Japan. [Sterneck, Esta] NCI, Lab Cell & Dev Signaling, Ctr Canc Res, Frederick, MD 21702 USA. [Johnson, Peter F.] NCI, Basic Res Lab, Ctr Canc Res, Frederick, MD 21702 USA. [Hedrick, Stephen M.] Univ Calif San Diego, Dept Cell & Mol Biol, La Jolla, CA 92093 USA. [Hedrick, Stephen M.] Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USA.
    1. Year: 2009
  2. Journal: Science
    1. 324
    2. 5929
    3. Pages: 938-941
  4. Type of Article: Article
  1. Abstract:

    A surge of luteinizing hormone (LH) from the pituitary gland triggers ovulation, oocyte maturation, and luteinization for successful reproduction in mammals. Because the signaling molecules RAS and ERK1/2 ( extracellular signal-regulated kinases 1 and 2) are activated by an LH surge in granulosa cells of preovulatory follicles, we disrupted Erk1/2 in mouse granulosa cells and provide in vivo evidence that these kinases are necessary for LH-induced oocyte resumption of meiosis, ovulation, and luteinization. In addition, biochemical analyses and selected disruption of the Cebpb gene in granulosa cells demonstrate that C/EBPb (CCAAT/Enhancer-binding protein-beta) is a critical downstream mediator of ERK1/2 activation. Thus, ERK1/2 and C/EBPb constitute an in vivo LH-regulated signaling pathway that controls ovulation- and luteinization-related events.

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  2. DOI: 10.1126/science.1171396
  3. PMID: 19443782

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