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Limb Development: The Rise and Fall of Retinoic Acid

  1. Author:
    Lewandoski, M.
    Mackem, S.

  2. Author Address

    Lewandoski, Mark, Mackem, Susan] NCI, Canc & Dev Biol Lab, Frederick, MD 21702 USA.
    1. Year: 2009
  2. Journal: Current Biology
    1. 19
    2. 14
    3. Pages: R558-R561
  4. Type of Article: Editorial Material
  1. Abstract:

    Retinoic acid was thought to play a key instructive role during limb bud initiation and subsequent patterning. New results argue instead that its role is permissive: retinoic acid is essential only to antagonize early axial Fgf signals that otherwise inhibit the limb field.

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  2. DOI: 10.1016/j.cub.2009.06.017
  3. PMID: 19640492

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