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Disease-specific gene repositioning in breast cancer

  1. Author:
    Meaburn, K. J.
    Gudla, P. R.
    Khan, S.
    Lockett, S. J.
    Misteli, T.

  2. Author Address

    Meaburn, Karen J.; Khan, Sameena, Misteli, Tom] NCI, NIH, Bethesda, MD 20892 USA. [Gudla, Prabhakar R.; Lockett, Stephen J.] Sci Applicat Int Corp Frederick Inc, Opt Microscopy & Anal Lab, Adv Technol Program, Frederick, MD 21702 USA. [Gudla, Prabhakar R.; Lockett, Stephen J.] NCI, Frederick, MD 21702 USA.
    1. Year: 2009
  2. Journal: Journal of Cell Biology
    1. 187
    2. 6
    3. Pages: 801-812
  4. Type of Article: Article
  5. ISSN: 0021-9525
  1. Abstract:

    Genomes are nonrandomly organized within the three-dimensional space of the cell nucleus. Here, we have identified several genes whose nuclear positions are altered in human invasive breast cancer compared with normal breast tissue. The changes in positioning are gene specific and are not a reflection of genomic instability within the cancer tissue. Repositioning events are specific to cancer and do not generally occur in noncancerous breast disease. Moreover, we show that the spatial positions of genes are highly consistent between individuals. Our data indicate that cancer cells have disease-specific gene distributions. These interphase gene positioning patterns may be used to identify cancer tissues.

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  2. DOI: 10.1083/jcb.200909127
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