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Determinants and Correlation of Systemic and Cervical Concentrations of Total IgA and IgG

  1. Author:
    Safaeian, M.
    Kemp, T.
    Falk, R. T.
    Rodriguez, A. C.
    Hildesheim, A.
    Williams, M.
    Porras, C.
    Herrero, R.
    Pinto, L. A.

  2. Author Address

    Safaeian, Mahboobeh] NCI, Div Canc Epidemiol & Genet, Infect & Immunoepidemiol Branch, NIH, Rockville, MD 20852 USA. [Kemp, Troy, Williams, Marcus, Pinto, Ligia A.] NCI, HPV Immunol Lab, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21701 USA. [Rodriguez, Ana Cecilia, Porras, Carolina, Herrero, Rolando] Fdn INCIENSA, San Jose, Costa Rica.
    1. Year: 2009
  2. Journal: Cancer Epidemiology Biomarkers & Prevention
    1. 18
    2. 10
    3. Pages: 2672-2676
  4. Type of Article: Article
  1. Abstract:

    We compared systemic and cervical total IgA and IgG during the menstrual cycle among 154 women who attended clinic visits at follicular/early, periovulatory/mid, and luteal/late phases of menstrual cycle. Paired serum and cervical secretions were tested at each visit for total IgA and IgG using ELISA. Geometric mean titers for systemic IgA and IgG were 1.92 and 8.25 mg/mL, respectively. There were no differences in titers by menstrual cycle phase, neither were they correlated to cervical titers (rho = 0.17 and 0.16, respectively). The lack of correlation between systemic and cervical total IgA and IgG suggests that systemic concentrations are not reflective of cervical levels. (Cancer Epidemiol Biomarkers Prev 2009,18(10):2672-6)

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  2. DOI: 10.1158/1055-9965.epi-09-0348
  3. PMID: 19815637

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