Skip NavigationSkip to Content
Return Return to Search Results

Cutting Edge: Tumor-Specific CD8(+) T Cells Infiltrating Prostatic Tumors Are Induced to Become Suppressor Cells

  1. Author:
    Shafer-Weaver, K. A.
    Anderson, M. J.
    Stagliano, K.
    Malyguine, A.
    Greenberg, N. M.
    Hurwitz, A. A.

  2. Author Address

    Shafer-Weaver, Kimberly A.; Anderson, Michael J.; Stagliano, Katherine, Hurwitz, Arthur A.] NCI, Tumor Immun & Tolerance Sect, Mol Immunoregulat Lab, Canc & Inflammat Program, Frederick, MD 21702 USA. [Shafer-Weaver, Kimberly A.; Malyguine, Anatoli] SAIC Frederick Inc, Lab Cell Mediated Immun, Frederick, MD 21702 USA. [Greenberg, Norman M.] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA.
    1. Year: 2009
  2. Journal: Journal of Immunology
    1. 183
    2. 8
    3. Pages: 4848-4852
  4. Type of Article: Article
  1. Abstract:

    We previously reported that naive, tumor-specific CD8(+) (TcR-I) T cells transferred into prostate tumor-bearing mice traffic to the prostate where they become tolerized. We now report that TcR-I cells suppress the proliferation of naive T cells. This suppression is mediated at least in part by secreted factors, and the suppressive activity can be blocked by Abs directed against TGF-beta. We further report that TcR-I cells must infiltrate the prostate to acquire suppressive activity. Delivery of tumor-specific CD4(+) T cells prevents the conversion of TcR-I cells into suppressor cells. Taken together, our findings may have critical implications for sustaining T cell responsiveness during immunotherapy, as the development of suppressor cells in the tumor microenvironment may eliminate the potency of T cells primed in the periphery or delivered during adoptive immunotherapy. The Journal of Immunology, 2009, 183: 4848-4852.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.4049/jimmunol.0900848
  3. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel