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Identification of a new prostate cancer susceptibility locus on chromosome 8q24

  1. Author:
    Yeager, M.
    Chatterjee, N.
    Ciampa, J.
    Jacobs, K. B.
    Gonzalez-Bosquet, J.
    Hayes, R. B.
    Kraft, P.
    Wacholder, S.
    Orr, N.
    Berndt, S.
    Yu, K.
    Hutchinson, A.
    Wang, Z. M.
    Amundadottir, L.
    Feigelson, H. S.
    Thun, M. J.
    Diver, W. R.
    Albanes, D.

  2. Author Address

    Yeager, Meredith, Hutchinson, Amy, Wang, Zhaoming] NCI, Core Genotyping Facil, SAIC Frederick Inc, Frederick, MD 21701 USA. [Yeager, Meredith, Chatterjee, Nilanjan, Ciampa, Julia, Gonzalez-Bosquet, Jesus, Hayes, Richard B.; Wacholder, Sholom, Orr, Nick, Berndt, Sonja, Yu, Kai, Hutchinson, Amy, Wang, Zhaoming, Amundadottir, Laufey, Albanes, Demetrius, Weinstein, Stephanie, Tucker, Margaret, Hoover, Robert N.; Fraumeni, Joseph F., Jr.; Thomas, Gilles, Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA. [Jacobs, Kevin B.] Bioinformed Consulting Serv, Gaithersburg, MD USA. [Kraft, Peter, Schumacher, Fredrick R.; Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA. [Feigelson, Heather Spencer, Thun, Michael J.; Diver, W. Ryan] Amer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA. [Virtamo, Jarmo] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland. [Schumacher, Fredrick R.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Cancel-Tassin, Geraldine, Cussenot, Olivier, Valeri, Antoine] Hop Tenon, CeRePP, AP HP, F-75970 Paris, France. [Andriole, Gerald L.] Washington Univ, Sch Med, Div Urol Surg, St Louis, MO 63110 USA. [Crawford, E. David] Univ Colorado Denver & Hlth Sci Ctr, Dept Surg, Denver, CO USA. [Haiman, Christopher A.; Henderson, Brian] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA. [Kolonel, Laurence, Le Marchand, Loic] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA. [Siddiq, Afshan, Riboli, Elio] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England. [Key, Timothy J.] Univ Oxford, Canc Epidemiol Unit, Oxford, England. [Kaaks, Rudolf] German Canc Res Ctr, Div Clin Epidemiol, DKFZ, D-6900 Heidelberg, Germany. [Isaacs, William, Isaacs, Sarah, Wiley, Kathleen E.] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA. [Gronberg, Henrik, Wiklund, Fredrik] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. [Stattin, Par] Umea Univ, Dept Surg Preoperat Sci Urol & Androl, Umea, Sweden. [Xu, Jianfeng, Zheng, S. Lilly, Sun, Jielin] Wake Forest Univ, Bowman Gray Sch Med, Ctr Canc Genom, Winston Salem, NC USA. [Vatten, Lars J.; Hveem, Kristian] Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, N-7034 Trondheim, Norway. [Kumle, Merethe] Univ Tromso, Inst Community Med, Tromso, Norway. [Gerhard, Daniela S.] NCI, Off Canc Genom, NIH, DHHS, Bethesda, MD 20892 USA. [Hunter, David J.] Harvard Univ, Brigham & Womens Hosp, Channing Lab, Sch Med, Boston, MA 02115 USA.
    1. Year: 2009
  2. Journal: Nature Genetics
    1. 41
    2. 10
    3. Pages: 1055-1057
  4. Type of Article: Article
  1. Abstract:

    We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24, homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

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  2. DOI: 10.1038/ng.444
  3. PMID: 19767755

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