Skip NavigationSkip to Content
Return Return to Search Results

Competitiveness for the Niche and Mutual Dependence of the Germline and Somatic Stem Cells in the Drosophila Testis Are Regulated by the JAK/STAT Signaling

  1. Author:
    Singh, S. R.
    Zheng, Z. Y.
    Wang, H.
    Oh, S. W.
    Chen, X.
    Hou, S. X.

  2. Author Address

    [Singh, Shree Ram; Zheng, Zhiyu; Wang, Hong; Oh, Su-Wan; Chen, Xiu; Hou, Steven X.] NCI, Mouse Canc Genet Program, NIH, Frederick, MD 21702 USA.;Singh, SR, NCI, Mouse Canc Genet Program, NIH, Frederick, MD 21702 USA.;singhshr@mail.nih.gov shou@mail.nih.gov
    1. Year: 2010
    2. Date: May
    3. Epub Date: 2/10/2010
  2. Journal: Journal of Cellular Physiology
    1. 223
    2. 2
    3. Pages: 500-510
  4. Type of Article: Article
  5. ISSN: 0021-9541
  1. Abstract:

    In many tissues, two or more types of stem cells share a niche, and how the stem cells coordinate their self-renewal and differentiation is poorly understood. In the Drosophila testis, germ line stem cells (GSCs) and somatic cyst progenitor cells (CPCs) contact each other and share a niche (the hub). The hub expresses a growth factor unpaired (Upd) that activates the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway in GSCs to regulate the stem cell self-renewal. Here, we demonstrate that the JAK/STAT signaling also regulates CPCs self-renewal. We also show that a negative regulator, the suppressor of cytokine signaling 36E (SOCS36E), suppresses JAK/STAT signaling in somatic cells, preventing them from out-competing the GSCs. Furthermore, through selectively manipulating the JAK/STAT signaling level in either CPCs or GSCs, we demonstrate that the somatic JAK/STAT signaling is essential for self-renewal and maintenance of both CPCs and GSCs. These data suggest that a single JAK/STAT signal from the niche orchestrate the competitive and dependent co-existence of GSCs and CPCs in the Drosophila testis niche. J. Cell. Physiol. 223: 500-510, 2010. (C) 2010 Wiley-Liss, Inc.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1002/jcp.22073
  3. PMID: 20143337
  4. PMCID: PMC2894562
  5. View record in Web of Science®
  6. WOS: 000276428100026
  7. NIHMSID: Nihms211491

Library Notes

  1. Fiscal Year: FY2009-2010
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel