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A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH

  1. Author:
    Liu, F.
    Hakami, R. M.
    Dyas, B.
    Bahta, M.
    Lountos, G. T.
    Waugh, D. S.
    Ulrich, R. G.
    Burke, T. R.

  2. Author Address

    [Liu, Fa; Bahta, Medhanit; Burke, Terrence R., Jr.] NCI, Biol Chem Lab, Mol Discovery Program, Ctr Canc Res,NIH, Frederick, MD 21702 USA. [Hakami, Ramin Mollaaghababa] Oak Ridge Associated Univ, Fac Res Participat Program, Belcamp, MD 21017 USA. [Hakami, Ramin Mollaaghababa; Dyas, Beverly; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Lab Mol Immunol, Frederick, MD 21702 USA. [Lountos, George T.; Waugh, David S.] NCI, Macromol Crystallog Lab, Ctr Canc Res, NIH, Frederick, MD 21702 USA.;Liu, F, Lilly Res Labs, Indianapolis, IN 46285 USA.;tburke@helix.nih.gov
    1. Year: 2010
    2. Date: May
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 20
    2. 9
    3. Pages: 2813-2816
  4. Type of Article: Article
  5. ISSN: 0960-894X
  1. Abstract:

    A bivalent tethered approach toward YopH inhibitor development is presented that joins aldehydes with mixtures of bis-aminooxy-containing linkers using oxime coupling. The methodology is characterized by its facility and ease of use and its ability to rapidly identify low micromolar affinity inhibitors. The generality of the approach may potentially make it amenable to the development of bivalent inhibitors directed against other phosphatases. Published by Elsevier Ltd.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.bmcl.2010.03.058
  3. View record in Web of Science®
  4. WOS: 000276816600024

Library Notes

  1. Fiscal Year: FY2009-2010
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