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Custodianship as an Ethical Framework for Biospecimen-Based Research

  1. Author:
    Yassin, R.
    Lockhart, N.
    del Riego, M. G.
    Pitt, K.
    Thomas, J. W.
    Weiss, L.
    Compton, C.

  2. Author Address

    [Yassin, Rihab] NCI, Div Canc Biol, Bethesda, MD 20892 USA. [Lockhart, Nicole; Compton, Carolyn] NCI, Off Biorepositories & Biospecimen Res, Bethesda, MD 20892 USA. [Pitt, Karen] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Thomas, Jeffrey W.] NCI, Technol Transfer Ctr, Bethesda, MD 20892 USA. [Weiss, Linda] NCI, Off Canc Ctr, Bethesda, MD 20892 USA. [del Riego, Mariana Gonzalez] Sci Applicat Int Corp Frederick Inc, Rose Li & Associates Inc, NCI Frederick, Frederick, MD USA.;Yassin, R, NCI, Div Canc Biol, 6130 Execut Blvd,Suite 5000, Bethesda, MD 20892 USA.;ry38k@NIH.gov
    1. Year: 2010
    2. Date: Apr
  2. Journal: Cancer Epidemiology Biomarkers & Prevention
    1. 19
    2. 4
    3. Pages: 1012-1015
  4. Type of Article: Editorial Material
  5. ISSN: 1055-9965
  1. Abstract:

    Human biological specimens (biospecimens) are increasingly important for research that aims to advance human health. Yet, despite significant proliferation in specimen- based research and discoveries during the past decade, research remains challenged by the inequitable access to high- quality biospecimens that are collected under rigorous ethical standards. This is primarily caused by the complex level of control and ownership exerted by the myriad of stakeholders involved in the biospecimen research process. This article discusses the ethical model of custodianship as a framework for biospecimen- based research to promote fair research access and resolve issues of control and potential conflicts between biobanks, investigators, human research participants (human subjects), and sponsors. Custodianship is the caretaking obligation for biospecimens frominitial collection to final dissemination of research findings. It endorses key practices and operating principles for responsible oversight of biospecimens collected for research. Embracing the custodial model would ensure transparency in research, fairness to human research participants, and shared accountability among all stakeholders involved in biospecimen- based research. Cancer Epidemiol Biomarkers Prev; 19(4); 1012-5. (C)2010 AACR.

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External Sources

  1. View Full Text
  2. DOI: 10.1158/1055-9965.epi-10-0029
  3. View record in Web of Science®
  4. WOS: 000278484400020

Library Notes

  1. Fiscal Year: FY2009-2010
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