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Influence of HLA Class I and HLA-KIR Compound Genotypes on HIV-2 Infection and Markers of Disease Progression in a Manjako Community in West Africa

  1. Author:
    Yindom, L. M.
    Leligdowicz, A.
    Martin, M. P.
    Gao, X. J.
    Qi, Y.
    Zaman, S. M. A.
    van der Loeff, M. S.
    van Tienen, C.
    Jaye, A.
    Aveika, A.
    Worwui, A.
    Diatta, M.
    Vincent, T.
    Whittle, H. C.
    Rowland-Jones, S. L.
    Walton, R.
    Carrington, M.

  2. Author Address

    [Martin, Maureen P.; Gao, Xiaojiang; Qi, Ying; Carrington, Mary] NCI, Expt Immunol Lab, SAIC Frederick Inc, Ft Detrick, MD 21702 USA. [Leligdowicz, Aleksandra; Rowland-Jones, Sarah L.] MRC, Human Immunol Unit, Oxford, England. [Zaman, Syed M. A.] Hlth Protect Agcy, Ctr Infect, London NW9 5EQ, England. [van der Loeff, Maarten Schim] GGD Amsterdam, NL-1000 CE Amsterdam, Netherlands. [van der Loeff, Maarten Schim] Ctr Infect & Immun Amsterdam, NL-1000 CE Amsterdam, Netherlands. [Walton, Robert] Barts & London Med Sch, Ctr Hlth Sci, London E1 2AT, England. [Carrington, Mary] MGH, Ragon Inst, Boston, MA 02114 USA. [Carrington, Mary] MIT, Boston, MA 02114 USA. [Carrington, Mary] Harvard Univ, Boston, MA 02114 USA.;Carrington, M, NCI, Expt Immunol Lab, SAIC Frederick Inc, Ft Detrick, MD 21702 USA.;carringm@mail.nih.gov
    1. Year: 2010
    2. Date: Aug
  2. Journal: Journal of Virology
    1. 84
    2. 16
    3. Pages: 8202-8208
  4. Type of Article: Article
  5. ISSN: 0022-538X
  1. Abstract:

    Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HLA-B*0801 is associated with susceptibility to infection. Interestingly, previous data indicate that HLA-B*1503 is associated with low viral loads in HIV-1 clade B infection but has no significant effect on viral load in clade C infection. In general, alleles strongly associated with HIV-1 disease showed no effect in HIV-2 disease. These data emphasize the unique nature of the effects of HLA and HLA/KIR combinations on HIV-2 immune responses relative to HIV-1, which could be related to their distinct clinical course.

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External Sources

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  2. DOI: 10.1128/jvi.00116-10
  3. View record in Web of Science®
  4. WOS: 000279983200027

Library Notes

  1. Fiscal Year: FY2009-2010
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